Novel surfactant SOE containing fluorine and a sulfonic group was synthesized using 1H，1H，2H，2H-Perfluoro- 1-decanol and sodium 2-chloroethanesulphonate in order to increase the permeability of aqueous phase and decrease the capillary pressure in ultra-low permeability sandstone reservoirs. This aimed to reduce injecting pressure and increase the amount of injected water. Moreover，SOE was combined with octylphenol polyoxyethylene（10）ether（OP-10）and sodium dodecyl benzene sulfonate （SDBS）respectively. The surface tension，oil-water interfacial tension and contact angle of SOE solution and the composite systems were investigated. The results showed that the surface activity and water non-wettability of SOE were obviously better than those of hydrocarbon surfactant and the interface activity of SOE was remarkably better than that of perfluorinated surfactant. The critical micelle concentration of SOE was 0.4 g/L in water or 30 g/L NaCl solution at 30°C. The oil-water interfacial tension of SOE solution was 2.80 mN/m，and the contact angle was up to 75.63° for this brine at this temperature. The synergism between SOE and hydrocarbon surfactant was good. When 0.08 mmol/L SDBS was added to 0.2 g/L SOE brine，the oil-water interfacial tension decreased obviously from 3.71 to 0.44 mN/m，and the contact angle changed slightly and remained 66.42°. Moreover，the amount of SOE would be decreased remarkably. The oil-water interface activity of SOE/SDBS composite system was markedly better than that of SOE/OP-10 in the brine. Therefore，the SOE/SDBS composite surfactant could be applied in the depressurization and injection augment for ultra-low permeability reservoir.