The effective period of film-forming sand control agent depended on the molecular adsorption performance onto the surface of reservoir rock. In order to prolong the effective period of film-forming sand control agent，the adsorption performance of some cationic compounds onto the rock surface was simulated by combining molecular simulation with Monte Carlo method.According to the results of molecular simulation，the amphiphilc cationic polymer was designed and synthesized as a new film-forming sand control agent. The erosion resistance performance of film-forming sand control agent was studied，and it was implemented in Shengli oilfield. The results of simulation computation showed that hexane diacid monomer （HDA） and cyclohexane diamine monomer could not be well dissolved in water，but could be well dissolved in oil. HDA-DM1 polyamide chain had relatively good adsorption performance with -56.34 kcal/mol adsorption energy on the surface of quartz，indicating good thermal and mechanical performance. The core flooding experiment results showed that HDA-DM1 had good wash-resistant ability which was 3 times higher than that of standard requirement. The film-forming sand control agent was applied on 10 wells successfully，the sand control effect was obvious and the sand control life extended.