In order to simulate the characteristics of Changqing ultra-low permeability reservoir and determine the reasonable exploitation method of residual oil after water flooding，oil displacement experiments were carried out by petroleum sulfonate surfactant， linear polymer and polymer/surfactant binary flooding， using three-dimensional physical model of artificial micro-fractured outcrop core and natural matrix outcrop in parallel. The experiment results showed that the physical property of three dimensional heterogeneous model was similar to that of actual reservoir，and the real situation of reservoir was simulated well.Compared with water flooding，the enhanced oil recovery rate of surfactant flooding in fracture surface，matrix layer and parallel core model was 2.65%，2.72% and 2.67%，that of polymer flooding was 5.65%，3.32% and 4.57%，and that of polymer/surfactant binary flooding was 8.23%，5.09% and 6.69%，respectively. Compared with surfactant flooding and polymer flooding，polymer/surfactant binary flooding effectively enhanced oil recovery which was expected to be used for oil displacement after water flooding in Changqing oilfield.