Most currently used friction reducer couldn’t tolerate high salinity of water that was used to prepare slickwater. In order to obtain the friction reducer that could be prepared by high salinity water，the research of hydrophobically associating polymer friction reducer GAF-RP with salt tolerance was carried out. The solubility，friction reducing property and salt tolerance of GAF-RP were evaluated. The friction reducing property，antiswelling property and damage to cores of slickwater system which was prepared by GAF-RP，synergist GAF-2D and clay stabilizer GAF-16 were studied，and the slickwater was applied on oilfield in Jilin province. The results showed that GAF-RP had better friction reducing property and salt tolerance than polyacrylamide based friction reducer. The dissolution time of GAF-RP was short and maximum friction reduction could be 80% within 120 s. GAF-RP could tolerate salinity up to 25×10⁴ mg/L and CaCl₂ content up to 1000 mg/L. Slickwater system prepared with GAF-RP had low surface tension（27.1 mN/m），high antiswelling capacity（antiswelling rate＞80%）and low damage（<5%）to matrix permeability.Flowback fluid of the slickwater could be reused and the new system had desired friction reducing property. The friction reduction of system prepared with GAF-RP was 78.2% in the field，the flowback rate was 49.6% and daily oil output was 4.3 t，showing good production performance.