Aiming at the problems of commonly drilling fluid lubricant，such as low pressure，poor anti-friction effect and temperature resistance， extreme pressure lubricant NH-EPL was prepared by introducing metal organic compound into alkanolamine ester. The properties of NH-EPL，such as lubrication，friction-reduction and wear-resistance effect，temperature resistance and salt tolerance，foam ability，fluorescence level and biological toxicity and so on，were studied and the effect of NH-EPL on the rheological property of drilling fluid was investigated. Furthermore，NH-EPL was applied in Xinjiang and Jiangsu area on site. The results showed that NH-EPL had excellent extreme pressure friction resistance and lubrication performance. At room temperature，the lubrication factor reduced 93.4% and the wear loss reduced 99.87% by 0.5% NH-EPL. The pressure capacity of NH-EPL was 320 kgf. NH-EPL had good resistance to temperature（160℃）and salt. The lubrication factor of 20% NaCl salt water slurry reduced 80.43% by NH-EPL. The foam ability of NH-EPL was poor and the foaming rate of base slurry containing 0.5% NH-EPL was only 1.0%. The fluorescence level of NH-EPL was one level. It had no biological toxicity which was in accordance with environmental guidelines. NH-EPL had little effect on the rheological property and filtration property of mud，and the compatibility between NH-EPL and other treatment agent was good. The field application effect of NH-EPL was remarkable in Xinjiang and Jiangsu area with drilling friction reduction rate up to 50%，which met the demand for drilling service of deep，highly-deviated and horizontal wells.