The latest research progresses of polyacrylamide biodegradation in recent years were reviewed. The composition and performance of the aerobic and anaerobic degrading microorganisms were introduced. The mechanisms and ways of polyacrylamide biodegradation were summarized. The thermodynamics parameters of Gibbs free energy during the polyacrylamide biodegradation were calculated and the dynamics property was discussed. The future research directions of polyacrylamide biodegradation was proposed.