Using white oil as the continuous phase, a blend of surfactants (Span80 and OP10) as emulsifying system and 40.0% aqueous solution of acrylamide as the dispersed phase, the inverse microemulsion was prepared, including 43% white oil, 24.7% Span80/OP10 (26:74) emulsifiers and 36.4% aqueous solution of acrylamide. The inorganic vermiculite was added in the polymerization system during the preparation of polyacrylamide inverse emulsion and the composite polyacrylamide microspheres (PAMCMS) with core-shell structure were obtained. Using the size, swelling property and emulsion stability as indicators, the effect of stirring speed, reaction time, and concentration of initiators and crosslinking agent on the polymerization were investigated. When the concentration of initiator and crosslinking agent was 0.09% and 0.025%, respectively, the latex particles with particle diameter of 680.4 nm could be obtained under stirring rate 300 r/min at the temperature of 40℃. The measurement of scanning electronic microscope and Laser particle diameter analyzer showed that the particle diameter of PAMCMS reached up to 2792 nm after swelling in deionized water for 10h, increased by nearly 4 times.