Chemical agent loss degree had direct effect on the utilization efficiency of Chemical slug. Previous studies mainly focused on static chemical agent adsorption degree on rock surface. Factors of influencing chemical agent loss degree could not be fully considered by this way. To solve this problem, the changes of surfactant and NaOH mass fraction, composition of surfactant and interfacial tension were systematically investigated after the adsorption of alkali/surfactant/polymer (ASP) system in multiple oil sand and crude oil. The composition of ASP was obtained as follows: 1.5 g/L hydrolyzed polyacrylamide (HPAM), 0.3% ceiling mass fraction of surfactant, and 1.2% ceiling mass fraction of NaOH. The results showed that both rock surface adsorption and oil phase adsorption not only reduced the mass fraction of surfactant and NaOH, but also change the composition of surfactant, and eventually led to the changes of interfacial tension between ASP system and crude oil. The mass fraction of surfactant decreased from 0.28% to 0.02%, and that of NaOH decreased from 1.10% to 0.71% for ASP system after 7 times oil sand adsorption. In addition, the interfacial tension between ASP system after 5 times oil sand adsorption and crude oil could not be reduced to 10^-3 mN/m order of magnitude. For ASP system after mixing with the crude oil, the mass fraction of surfactant decreased substantially and the largest decline reached 50%, while the molecular weight of surfactant obviously increased. Compared with surfactant, the mass fraction variation of NaOH was smaller with largest fall of only 15.22%. The interfacial tension between ASP system after 3 times oil sand adsorption and crude oil greatly increased which could not be reduced to 10^-3 mN/m order of magnitude after mixing with the crude oil. In order to comprehensively evaluate the changes of above properties, a new evaluation method was proposed which combined multiple sand adsorption with crude oil adsorption.