CO2 foam has been used as an effective conformance and mobility control agent to prevent early gas breakthrough during CO2 flooding in heterogeneous reservoirs. In this study, the performance of CO2 foams generated using various surfactants was investigated. The effects of surfactant concentration, temperature, salinity and pressure on performance of CO2 foam were studied under high temperature and high salinity conditions prevailed in Zhongyuan oilfield. The performance of the CO2 foam on mobility control was measured via flooding and displacement experiments using sandpacks. The results showed that the complex of amphoteric surfactants LX-8 and nonionic surfactants FL-6 with HLB values between 14 and 16 had good foam stability at high temperature and salinity conditions. The resistance factor of foams generated in sandpacks could reach up to 130 under 100℃ and 15 MPa, indicating that the CO2 foams had good mobility control and sealing capabilities at reservoir conditions. The experimental results also showed that the resistance was more sensitive to half life time of the CO2 foam, which could be the main factor to evaluate CO2 foam’s stability and blocking performance.