According to the high temperature condition in Zhaowa block of Henan oilfield, the optimum formula of polymer cross-linking system was obtained as follows: 1.5 g/L comb polymer KY-6, 15 g/L aldehyde cross-linking agent. The optimum gelation temperature was about 90℃. This profile control agent had resistance of temperature 110℃ and salinity 20 g/L. The viscosity retention rate of gel was more than 80% after 90 days at 90℃ gelling temperature. The storage modulus of the gel was above 10 Pa which showed it was strong gel. The physical model results showed that the blocking ratio of the profile control agent in core was more than 96%, and the retention rate of blocking ratio was beyond 99% after water scouring. Sand packed tube model experiment results showed that the increase of oil recovery was up to 15.91%, with 0.3 PV injection and slug combination of lead slug, subject slug and rear slug. Parallel core profile control experiment results showed that the improving rate of injection profile was up to 88% after profile control. Recovery efficiency of high and low permeability layers was improved by 14.13% and 19.28%, respectively. Water driving degree of different permeability core was improved.