Because there are many surfactants in the domestic styrene-butadiene latex, the foams could be produced and existed stably in the cement slurry though the mixing process, which would seriously influence the density and compressive strength of the cement pastes. In this paper, the surface tension and stability of the latex was tested and the flowability and density at different temperature was measured and the compressive strength and microstructure of the cement pastes with or without defoamers were studied as well. The results showed that the influence of the concentration of styrene-butadiene latex was lower than that of the type of the defoamers. Moreover, the foaming reaction of cement slurry with latex at high temperature was intenser than in room temperature. The surface tensile and defoamers of isooctanol as well as dimethicone was much lower than that of the others, and the both defoamers which had a good defoaming ability at 90℃would not effect the stability and flowability of the latex cement slurry, however, the defoaming effect was the best at the dosage of 0.3%. After adding the compound defoamers (the mass ratio of dimethicone to isooctanol was 1:1.5) in the latex cement slurry, the compressive strength of the obtained cement paste was much higher and the number of pore and bubble in the cement paste was fewer than that without defoamers, meaning that the microstructure of the cement paste with compound defoamers was denser.