In order to meet the requirements of integrated technology of water plugging and acidification, the cationic polymer thickener with 800—12 million molecular weight was synthesized in laboratory by the method of polymerization in solution using acrylamide, dimethyl diallyl ammonium chloride and methyl propenyl acyloxy ethyl three alkyl ammonium chloride. Indoor evaluation experiment results showed that the optimum dosage of thickener was of 1.0% and the soluble time of thickener was of 30 min in 5% and 10% HCl solution. When 5% and 10% HCl solutions were taken as a contrast to analysis the thickener performance, the initial viscosity of acid system was of 31.0 mPa·s and 26.8 mPa·s, respectively. After refluxing 1 h at 72℃, the viscosity loss rate was of 21.94% and 32.46%, and that was of 39.67% and 36.12% after soaking 48 min in acid. But after cross-linking reaction, gel viscosity was more than 100 Pa·s, and gelation time was less than 8 hrs. Salt resistance experiment results showed that the soluble time extended with increasing salinity, but the initial viscosity of acid system, the viscosity of gel and gelation time were not affected. The thickener could meet the requirements of integrated technology of water plugging and acidification.