In this paper,in view of the properties of reservoir and oil in KMK oilfield of Kazakhstan,the major factors influencing the reaction process,including the concentration of the initiator and the initial temperature,were researched through the laboratory experiments,and the effects of thermo-chemical reaction on the viscosity reduction of the KMK crude oil were evaluated.The results showed that,the higher the concentration of initiator was,the faster the reaction velocity was and the higher the peak temperature was;the higher the initial temperature was,the more the gas volume was.In the pretreatment section,the heat released from the system reaction could reduce the viscosity of the crude oil and dissolve the organic substances to improve the oil flowability and enhance the oil recovery.The results of the simulation experiments indicated that significant effects in KMK oilfield would be achieved by adopting the heavy oil thermo-chemical production technology.