In view of the problems such as poor washing resistance of inorganic salt clay stabilizer, easy adsorption and blockage of pore channel and poor temperature resistance of polymer clay stabilizer, it is urgent to develop a new type of small molecule clay stabilizer for high temperature and low permeability reservoir. In this work, high temperature resistant clay stabilizer ZWS-1 was synthesized with trimethylamine and γ-chloropropyltriethoxysilane. The optimized weight concentration of ZWS-1 applied for clay stabilization was 1.5%. A synergistic effect was observed on 5% ZWS-1 and 4% KCl, which exhibited a decrement of clay swelling of 98.3%, and the washing resistance of 91.4% at 150 ℃. The characterization results indicate that ZWS-1 leads to the agglomeration of clay particles and increase the stability of clay. Fourier transform infrared spectroscopy (FTIR) results reveal that ZWS-1 reacts with hydroxyl groups of the clay surface, which indicates that the presence of chemical bond between ZWS-1 and clay minerals.