In order to reduce the risk of environmental protection and meet the drilling requirements of extended reach well and horizontal well，antifriction and resistance reducer NH-JZ was prepared by introducing a variety of active elements and metal elements into long chain polyhydric alcohol amine and reacting with fatty acids，and then adding compound emulsifier. The lubrication property，antiwear and antifriction property，foaming property，temperature resistance property，fluorescence level，biological toxicity and compatibility with drilling fluid of NH-JZ were studied. Finally，NH-JZ was applied in 17 wells of Sinopec and PetroChina. The results showed that NH-JZ had excellent lubrication property，antiwear and antifriction property. When 0.5% NH-JZ was added into the bentonite drilling fluid，the reduction rate of lubrication coefficient and the wear loss at room temperature was 90.41% and 99.98% respectively. When 2.0% NH-JZ was added into the weighted drilling fluid whose density was 2.05 g/cm3，the reduction rate of lubrication coefficient and the wear loss at room temperature was 86.87% and 88.52% respectively. NH-JZ could form high strength extreme pressure film，and the pressure capacity of NH-JZ was 360 kgf. NH-JZ had excellent resistance to temperature and the lubricity remained stable at 200℃. NH-JZ was non-toxic，low fluorescence，and had good compatibility with polyamine polymer drilling fluid system，polysulfonate drilling fluid system and organic salt drilling fluid system. Field application results showed that NH-JZ could significantly improve the lubricity of drilling fluid，effectively reduce the friction and torque，and could be used in extended reach directional well，directional well and long horizontal well.