In order to simplify the preparation process of slick water and reduce the cost of field fracturing construction，using acrylamide （AM） and methacryloxyethyl dimethyl octadecyl ammonium bromide （DH-1） as raw materials， 2， 2'-azodiisobutamidine hydrochloride（V50）as initiator，an anti-salt associative thickener（GAF-KYTP）was synthesized，which could be used not only as a drag-reducing agent for slick water，but also as a gel thickener. When the fracturing fluid was prepared by flow-back fluid，a set of multi-functional complex fracturing fluid（sliding water+glue）system with the same type and different dosage of additives was prepared by optimizing the dosage of GAFKYTP，zirconium organic crosslinker GAF-5 and fluorocarbon additive GAF-6. The resistance reduction，temperature and shear resistance and core damage of fracturing fluid were evaluated. Finally the fracturing fluid was applied in Weiyuan block. The results showed that GAF-KYTP had good salt resistance and viscosity increasing performance in flow-back fluid. The slick water with formula of 0.06% GAF-KYTP+0.1% GAF-6 had fast dissolution speed，79% indoor resistance reduction rate and 78.3% field resistance reduction rate，indicating good resistance reduction effect. The glue with formula of 0.4% GAF-KYTP + 0.2% GAF-6 + 0.3% GAF-5 had good temperature and shear resistance，whose viscosity was 82.6 mPa s after shearing for 1 h at 90℃ and 170 s^-1. The damage rate of slick water and glue prepared by GAF-KYTP to core matrix permeability was less than 10%. The development of this system improved the problem of complex technology of on-site slippage and simultaneous preparation of glue due to different additives in shale gas production in China，and the problem of poor salt resistance of gel thickener，which made it impossible to use flow-back fluid.