In order to study the application of core experimental data in numerical simulation， the relationship between the dynamic adsorption capacity of n-butanol and sodium dodecyl sulfate in natural cores with permeability of 10 × 10^-3—15 × 10^-3 μm²and their concentration was measured， which could provide basic dynamic adsorption parameters for numerical simulation. A micro-emulsion system was prepared with crude oil， n-butanol and sodium lauryl sulfate as main agents， and the threshold pressure gradient of microemulsion system in low permeability natural cores was determined using the differential pressure flow method， and the displacement experiment was carried out. The experimentally measured parameters were applied to the numerical simulation software CMG for small-scale numerical simulation of cores. The results showed that as for the core with the permeability of 10× 10^-3—15×10^-3μm²， the adsorption equilibrium of the sodium lauryl sulfate and n-butanol could be reached， respectively， when their mass fraction was 4% and 10%， respectively， and their dynamic adsorption capacity was 4.2 mg/g and 3.2 mg/g ， respectively. The dynamic adsorption capacity of n-butanol and sodium dodecyl sulfate measured in the core experiment could be directly used in the numerical simulation， while the experimentally measured threshold pressure gradient need to be adjusted appropriately. The adjusted simulation results was in good agreement with the actual core experiment.